Immune response to Cryptococcus neoformans soluble polysaccharide: immunological unresponsiveness
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منابع مشابه
Immune response to Cryptococcus neoformans soluble polysaccharide: immunological unresponsiveness.
Mice injected with 100 to 800 microgram of Cryptococcus neoformans soluble polysaccharide showed a reduced ability to produce antibody after a challenge immunization with polysaccharide emulsified in Freund incomplete adjuvant. These animals were considered immunologically unresponsive. Animals given an initial injection of 25 or 50 microgram of polysaccharide responded to a challenge immunizat...
متن کاملImmune response to Cryptococcus neoformans soluble polysaccharide. I. Serological assay for antigen and antibody.
Chromium chloride was used as a coupling agent for the conjugation of purified cryptococcal polysaccharide to sheep erythrocytes. Sensitized erythrocytes were used in a passive hemagglutination (PHA) assay for antibody to cryptococcal polysaccharide and a passive hemagglutination inhibition (PHI) assay for antigen. The PHA assay was more sensitive than complement fixation, agglutination, or pre...
متن کاملAllergen1 regulates polysaccharide structure in Cryptococcus neoformans.
Cryptococcus neoformans is an important human, fungal pathogen that sheds polysaccharide (exo-PS) into host tissues. While shed exo-PS mediates numerous untoward effects (including promoting increased intracranial pressure), little is known about the regulation of this phenomenon. Since downregulation of the Allergen 1 (ALL1) gene is associated with high ICP, we investigated the relationship be...
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Immunologic unresponsiveness (paralysis) to pneumococcal polysaccharide, first described in detail by Felton (1-5), represents a simple, easily manipulated model for the study of the unresponsive state. I t is now generally agreed that paralysis to polysaccharides and unresponsiveness to protein antigens are both expressions of the same basic biologic mechanisms (6). Current evidence supports t...
متن کاملEpidemiological and immunological studies of Cryptococcus neoformans.
Walter, Jinks E. (University of Pittsburgh, Pittsburgh, Pa.), and Robert W. Atchison. Epidemiological and immunological studies of Cryptococcus neoformans. J. Bacteriol. 92:82-87. 1966.-The complement-fixation fluorescent-antibody test provided a means of differentiating between antibodies of Cryptococcus neoformans and Candida albicans. The test was applied to the sera of 134 pigeon fanciers f...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1977
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.18.3.701-707.1977